Job Description

Principal Scientist, Computational Biology - Genotoxicity

Join to apply for the Principal Scientist, Computational Biology - Genotoxicity role at Tessera Therapeutics .

Your Experience Includes…

• Ph.D. (or comparable experience) in Computational Biology, Bioinformatics, or related quantitative discipline.
• 8+ years of experience in discovery research in an industrial or academic setting focused on gene therapy.
• Proficient with experimental design, data processing, statistical analysis, and bioinformatics analysis/reporting of next-generation sequencing data. A strong experimental knowledge is welcome.
• Experienced in developing methodologies and analyzing data for genotoxicity assessments in gene editing applications.
• Experience developing and characterizing gene therapy platforms, preferably in the gene editing space.
• Expertise in the central concepts of data structures and cloud computing.
• Fluency in one or more programming languages with bioinformatics applications (R, Python).
• Track record of success working in a fast-paced, cross-functional, and rapidly growing organization.
• Improved written and verbal communication skills, ability to work with colleagues from diverse scientific backgrounds and cultures.

You are interested in…

• Significant experience with recent advances in gene therapy and development of gene editing platforms as therapeutics.
• Familiarity with computational methods for understanding molecular results of gene editing outcomes including on-target, off-target, and structural variants, from in silico to in cellula and in vitro methods.
• Familiarity with short and long read next-generation sequencing platforms (Illumina, PacBio, Nanopore).
• Proficiency in handling large scale sequencing data in a cloud environment (AWS preferred).
• Proficiency in statistics.
• It’s a bonus if you have experimental training.

About you:

We are seeking a highly motivated scientist with a strong computational background and significant experience in biological research. As part of the Computational Biology team, you will collaborate closely with Platform teams to advance our technologies and deepen our understanding of reagent biology. Your role will involve (1) working with biologists to design experiments, (2) developing methods and tools for processing and interpreting molecular data, and (3) presenting findings to an interdisciplinary audience. Your curiosity and passion will fuel your discoveries, while strong connections with biologists and data/software engineers will amplify the impact of your work.

Meet your Manager:

Andrea Calabria - Director, Computational Sciences
Andrea holds a B.Sc. and M.Sc. in Engineering from the Polytechnic of Milan (Italy) and earned a Ph.D. in Computer Science from the University of Milan Bicocca (Italy), specializing in computational biology. He has over 11 years of postdoctoral experience in gene therapy at the San Raffaele Telethon Institute for Gene Therapy in Milan, where he became a recognized researcher (H-index: 24, ORCID: His work focused on assessing the safety and insertional mutagenesis of gene therapy treatments using viral vectors and investigating human hematopoietic stem cell differentiation in vivo through clonal dynamics.

Andrea joined Tessera in 2023 as the lead of the computational biology team, where he is responsible for:

• Supporting drug candidate programs by developing genotoxicity packages,
• Leading research projects to identify novel reagents and uncover their biological mechanisms, and
• Overseeing technical initiatives, including database development for knowledge mining and molecular assay design.

Meet your Talent Partner:

Narissa Furtado-Cordeiro - Manager, Talent Acquisition
Narissa joined the Biotechnology industry shortly after graduating with her BS in Marketing from Franklin Pierce University. She is currently pursuing a MS in Legal Studies from Northeastern University School of Law while working full time as a Manager in Talent Acquisition at Tessera. She is passionate about helping individuals find a fulfilling opportunity while considering their interests, aspirations and technical skills.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Equal Opportunity Employer:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.

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